Estroven Active Ingredients

Estroven® has been on the market since late 1997, and all of its ingredients have been carefully chosen based on the best scientific information available. There are no known significant side effects directly attributed with the recommended serving sizes of Estroven®.

Safe and Naturally-Sourced Ingredients
Estroven’s line of multi-symptom menopause dietary supplement products have been developed with ingredients that either reside in nature or are naturally sourced.* Many of these ingredients, which have been around for centuries, have a relatively long safety profile history and have demonstrated efficacy supporting their use to relieve perimenopause/menopausal symptoms.*

The two primary ingredients in all of our menopause supplement products — Soy Isoflavones and Black Cohosh — both have long and safe histories of use.

Here is more detailed information on the origins of active ingredients used in Estroven menopause dietary supplement products.

There has been much safety research done on Black Cohosh Root. It is important to note that the kind of black cohosh used in Estroven® products is Cimicifuga racemosa, the North American herb, rather than the Asian variety, which may not have the same degree of purity or effectiveness.

Black Cohosh is a rich source of natural compounds that has been shown to help reduce hot flashes.* It has been used for centuries throughout the world to provide support for many areas of female health. There are different varieties of this herb; however, the type of Black Cohosh used in Estroven products is Cimicifuga racemosa, a native perennial North American plant. Renowned for its long tradition as a beneficial herbal remedy for the relief of moderate to severe menopausal symptoms related to the automatic nervous system (e.g., hot flushes, insomnia, nocturnal sweating, dizziness, headaches), black cohosh is used to alleviate psychological menopausal symptoms (e.g., irritability, anxiety).*1 There has been much safety research done on Black Cohosh. It is important to note that the kind of black cohosh used in Estroven®, is the North American herb, rather than the Asian variety, which may not have the same degree of purity or effectiveness.

Some of the leading medical journals have supported the use of American grown black cohosh to reduce menopause symptoms, including the Journal of Women’s Health, which states, "The evidence to date suggests that black cohosh is safe and effective for reducing menopausal symptoms, primarily hot flashes and possibly mood [changes]."* The North American Menopause Society (NAMS) recommends dietary Soy Isoflavones, Black Cohosh, or vitamin E for women who need mild relief from hot flashes and night sweats.*

Germany's Kommission E, a governmental regulatory body similar to the U.S. Food & Drug Administration (FDA), has approved the use of Black Cohosh for menopausal symptoms.* This scientific panel, which has done its own investigation and review of the safety and efficacy of North American Cimicifuga racemosa, has concluded that it is useful and warranted in helping these menopause symptoms.*

Soybeans (and other plants in the legume family like peanuts, chick peas, fava beans, alfalfa and kudzu) are very rich sources of the phytonutrient isoflavones. Isoflavones are vegetable substances, which can act on some of the same receptors as estrogen in the body.*

There has long been an association of a reduction in menopausal symptoms with the consumption of these biologically active molecules called isoflavones.* Of the three main types of isoflavones (genistein, daidzein, and glycitein), genistein and daidzein have protective functions that have been shown to be the most effective in helping to reduce hot flashes and night sweats.*

The soybean has been consumed by many women as a natural solution for treating menopausal symptoms such as hot flashes and night sweats.* Soybeans have the highest amounts of genistein and daidzein, which are said to be responsible for its therapeutic effects. One review that analyzed various trials according to the specific isoflavones contained in commercially available supplements found that supplements containing high amounts of genistein significantly reduce hot flash symptoms.*3 Because high amounts of genistein are important, the soy isoflavones concentrates used in the Estroven products maintain closely the isoflavones ratios of the whole soy beans.

There is no known evidence that the consumption of large amounts of isoflavones is harmful in humans as soy has been a dietary staple in many countries for more than 5,000 years. In studies of purified isoflavones, it has been shown that even large amounts of isoflavones, those exceeding normal dietary intakes, had minimal clinical toxicity in healthy postmenopausal women and the data further indicates that chronic dosing would not lead to an accumulation of isoflavones in the body.4

Estroven dietary supplements that contain Black Cohosh and Soy:

  • Estroven Maximum Strength plus Energy
  • Estroven Weight Management
  • Estroven Intimacy
  • Estroven Nighttime
  • Estroven Stress, Mood & Memory
  • Estroven Energy
  • Estroven Perimenopause/Menopause Support + Weight Management

In addition to hot flashes and night sweats, irritability is a complaint of some women going through perimenopause/menopause. To help with irritability, Estroven adds Magnolia bark extract, a safe and naturally-sourced ingredient used for thousands of years in traditional Chinese medicine, to improve overall mental well-being.*

Magnolia bark, specifically, is noted as being effective at reducing the stress and anxiety that result in irritability.* Extracts of Magnolia officinalis (magnolia bark), are rich in the phytochemicals honokiol and magnolol, which have the ability to alleviate stress while producing a calming effect.* In recent human clinical studies in menopausal women, researchers demonstrated magnolia bark’s anxiolytic effects to reduce irritability.*6 To date, no significant toxicity or adverse effects have been reported in the clinical studies.

Estroven dietary supplements products that contain Magnolia Bark:

  • Estroven Maximum Strength plus Energy
  • Estroven Stress, Mood & Memory
  • Estroven Energy
  • Estroven Intimacy

Occasional sleeplessness is another menopausal symptom that can dramatically impact a woman’s quality of life. Melatonin promotes natural sleep and supports the regulation of circadian rhythms.* Melatonin has a clock-shifting effect and can help to regulate sleep-wake cycles in humans by advancing or delaying the sleep phase depending on the time of administration.*7 In human studies, acute toxicity of melatonin has been demonstrated to be extremely low.8

Estroven products that contain Melatonin:

  • Estroven Nighttime

Memory lapses is a symptom that affects menopausal women. Estroven uses Ginkgo Biloba to address memory concerns.*

Standardized Ginkgo extract, contains flavonoid glycosides and terpenoids and is commonly used as a memory and concentration enhancer. Ginkgo biloba has been studied in several clinical trials and was found in varying degrees to enhance cognitive performance, memory, and attention.*1,9,10 General clinical trials involving ginkgo extracts produced few adverse effects, which were typically the same as the placebo.1

Estroven product that contain Gingko Boloba:

  • Estroven Stress, Mood & Memory

Synetrim CQ is the brand name for a proprietary standardized extract of Cissus quadrangularis, a plant native to West Africa, Southeast Asia, and India. It has been used extensively in traditional medical practices for centuries to treat a range of maladies.1,2,3 The stems and leaves of the Cissus quadrangularis plant have specific beneficial attributes; phytochemical analyses indicates many physiologically important substances that can provide beneficial responses.3 Cissus quadrangularis has been clinically studied and has safely demonstrated support of weight management.*

Estroven products that contain Synetrim CQ:

  • Estroven Weight Management
  • Blumenthal, Mark. The ABC Clinical Guide to Herbs. Austin: American Botanical Council, 2003.
  • Liske, Eckehard. "Theraputic Efficacy and Safety of Cimicifuga Racemosa for Gynocologic Disorders." Advances in Natural Therapy 15.1 (1998): 45-53.
  • Williamson-Hughes, Patricia S., Brent D. Flickinger, Mark J. Messina, and Mark W. Empie. "Isoflavone Supplements Containing Predominantly Genistein Reduce Hot Flash Symptoms." Menopause 13.5 (2006): 831-39.
  • Bloedon, LeAnne T., A Robert Jeffcoat, Wlodek Lopaczynski, Michael J. Schell, Tracy M. Black, Kelly J. Dix, Brian F. Thomas, Craig Albright, Marjorie G. Busby, James A. Crowell, and Steven H. Zeisel. "Safety and Pharmacokinetics of Purified Soy Isoflavones: Singledose Administration to Postmenopausal Women." American Journal of Clinical Nutrition 76 (2002): 1126-137.
  • Agosta, C., M. Atlante, and C. Benvenuti. "Randomized Controlled Study on Clinical Efficacy of Isoflavones Plus Lactobacillus Sporogenes, Associated or Not With a Natural Anxiolytic Agent in Menopause." Minerva Ginecol 63.1 (2011): 11-17.
  • Burgess, H. J., V. L. Revell, T. A. Molina, and C. I. Eastman. "Human Phase Response Curves to Three Days of Daily Melatonin: 0.5 Mg Versus 3.0 Mg." Journal of Clinical Endocrinology & Metabolism 95.7 (2010): 3325-331.
  • Malhotra, Samir, Girish Sawhney, and Promila Pandhi. "The Therapeutic Potential of Melatonin: A Review of the Science." Medscape General Medicine. 6.2 (2004):46. Web. 8 Mar. 2012.
  • Cieza et al. “Effects of Ginkgo biloba on Mental Functioning in Healthy Volunteers.” Arch Med Res. 34.5 (2003):373-81.
  • Hartley et al. “Effects on Cognition and Mood in Postmenopausal Women of 1-Week Treatment with Ginkgo biloba.” Pharmacology, Biochemistry, and Behavior. 75 (2003):711-20.